Epitalon: Where Every Study Claim Came From
Each bracketed number points to a paper below. Free paper listings and full details help you find the source.
How the papers help you check a claim
The Russian group that made Epitalon published its first key cell paper here in 2003. An outside team added new work in 2025.
Most human and life-span papers came from the St. Petersburg group. Results from one team deserve more checking before you trust a broad claim.
A bracketed number beside a claim leads to the matching paper below. The paper tells you whether the test used people, animals, or cells.
Some papers cost money to open in full. PubMed, a free government list of medical papers, still shows the title and brief details.
I first check whether a test used people, animals, or dishes. That quickly shows how closely a claim applies to you.
- Khavinson VK, Bondarev IE, Butyugov AA. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-592. ↗
- Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life. Neuro Endocrinol Lett. 2003;24(3-4):233-240. ↗
- Anisimov VN, Khavinson VKh, Provinciali M, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202. ↗
- Araj SK, Brzezik J, Mądra-Gackowska K, Szeleszczuk Ł. Overview of Epitalon — Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025;26(6):2691. ↗
- Al-Dulaimi S, Thomas R, Matta S, Roberts T. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity. Biogerontology. 2025;26(5):178. ↗
- Khavinson VKh, Linkova NS, Kvetnoy IM, et al. Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture. Bull Exp Biol Med. 2012;153(2):255-258. ↗
- Khavinson VKh, Izmaylov DM, Obukhova LK, Malinin VV. Effect of epitalon on the lifespan increase in Drosophila melanogaster. Mech Ageing Dev. 2000;120(1-3):141-149. ↗
- Anisimov VN, Khavinson VKh, Provinciali M, et al. Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice. Bull Exp Biol Med. 2002;133(2):139-143. ↗
- Anisimov VN, Khavinson VKh, Morozov VG. Pineal peptide preparation epithalamin increases the lifespan of fruit flies, mice and rats. Mech Ageing Dev. 1998;103(2):123-132. ↗
- Anisimov VN, et al. Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM). Vopr Onkol. 2005;51(1):93-98. ↗
- Lezhava T, Monaselidze J, et al. Peptide Epitalon activates chromatin at the old age. Neuro Endocrinol Lett. 2003;24(3-4):144-147. ↗
- Anisimov VN, Khavinson VKh, et al. Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice. In Vivo. 2006;20(2):281-284. ↗
- Anisimov VN, Khavinson VKh, et al. Effect of Epitalon and Vilon treatment on mammary carcinogenesis in transgenic erbB-2/NEU mice. Vopr Onkol. 2002;48(1):33-37. ↗
- Khavinson VKh, Razumovsky M, et al. Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa. Neuro Endocrinol Lett. 2002;23(4):365-368. ↗
- Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress. Neuro Endocrinol Lett. 2002;23(5-6):455-458. ↗
- Kossoy G, Anisimov VN, Ben-Hur H, et al. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Lett. 2002;183(1):1-4. ↗